MOTS-C Peptide – Mitochondrial-Derived Metabolic Regulator | ≥98% Purity

MOTS-C is a mitochondrial-derived peptide (MDP) encoded within mitochondrial DNA and studied for its critical role in regulating cellular metabolism, energy homeostasis, and adaptive stress responses. As a signaling peptide involved in mitochondrial-to-nuclear communication, MOTS-C has emerged as a key focus in metabolic, longevity, and bioenergetics research.

Unlike conventional peptides encoded by nuclear DNA, MOTS-C originates from the mitochondrial genome, positioning it uniquely in studies involving mitochondrial function, metabolic efficiency, and systemic energy regulation.

Mechanism of Action

MOTS-C functions as a metabolic regulator by influencing key intracellular pathways associated with energy balance and cellular adaptation.

AMPK Pathway Activation

• Activates AMP-activated protein kinase (AMPK)
• Enhances glucose uptake and utilization
• Promotes fatty acid oxidation
• Supports overall metabolic homeostasis

Mitochondrial-Nuclear Signaling

• Facilitates communication between mitochondria and nucleus
• Regulates gene expression related to metabolism and stress response
• Supports cellular adaptation to metabolic stress

Insulin Sensitivity Modulation

• Improves insulin signaling pathways in research models
• Supports glucose regulation and metabolic efficiency
• Investigated in insulin resistance and metabolic disorder studies

Research Significance

MOTS-C is widely utilized in laboratory models exploring:

• Metabolic disorders and insulin resistance
• Obesity and energy balance regulation
• Aging and longevity pathways
• Mitochondrial function and bioenergetics
• Exercise physiology and endurance models
• Cellular stress adaptation mechanisms

Its role in regulating metabolism at the mitochondrial level makes it a valuable compound in advanced metabolic and longevity research.

Key Research Applications

• Insulin sensitivity and glucose metabolism studies
• AMPK activation and metabolic signaling research
• Fat metabolism and energy expenditure models
• Mitochondrial function and bioenergetics investigations
• Longevity and age-related decline research
• Exercise performance and endurance studies

Product Specifications

• Form: Lyophilized peptide
• Purity: ≥98%
• Peptide Class: Mitochondrial-derived peptide (MDP)
• Sequence:
  Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg

(Available quantities may vary by batch.)

Storage & Handling

• Store lyophilized MOTS-C peptide in a cool, dry environment protected from light.
• Reconstitute with bacteriostatic water prior to research use.
• After reconstitution, refrigerate and use within the recommended research timeframe.

Sold per vial. Requires bacteriostatic water for reconstitution.
For laboratory research use only. Not for diagnostic, therapeutic, or human consumption.